Biomarkers of Mucinous Tumors of the Ovary
نویسندگان
چکیده
Goli Samimia,b, Laurent Ozbunb, Michael E. Johnsonc, Samuel C. Mokc and Michael J. Birrerb Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD 20892, USA Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA Laboratory of Gynecologic Oncology, Brigham and Women’s Hospital Harvard Medical School, Boston, MA 02115, USA
منابع مشابه
Immunohistochemical Characterization of Normal Ovary and Common Epithelial Ovarian Neoplasm with a Monoclonal Antibody to Cytokeratin and Vimentin
Background & Objective: The common epithelial ovarian tumors are classified into serous, mucinous, clear cell, endometrioid, the Brenner, mixed, and undifferentiated types. Cytoskeleton intermediate filament composition of ovarian tissues indicates that the cytokeratin and vimentin are observed in ovarian surface epithelium along with the common ovaria...
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Background: About 90% ovarian cancers are epithelial and 10-15% of this group are mucinous. The treatment is the hysterectomy with bilateral salpingo-oophorectomy. However, most of these tumors occur in young women that have not yet given birth in which preservation of fertility should be considered. We present a case of huge mucinous cystadenoma and massive ascites managed by preserving uteru...
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The objective of the present study was to evaluate the frequency of ovarian tumors over a 20-year period and the age distribution of these tumors. A retrospective study was performed on ovarian tumors which were diagnosed in Shariati Hospital between 1976-1995, and had pathologic report. Frequency and age distribution of tumors were then evaluated. Of 493 evaluated ovarian neoplasia...
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Ovarian cancer is the most lethal gynecologic malignancy. The surface epithelial tumor is the most common type of ovarian cancer. Among these, the mucinous tumors account for 10-15% of ovarian tumors. Mucinous ovarian tumors are among the most difficult ovarian neoplasms for surgical pathologists to interpret. Mucinous tumors sometimes coexist with other surface epithelial tumors. Therefore, ma...
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Background: Ovarian mucinous borderline tumors are divided into two morphologic groups: endocervical-like and intestinal type. Most endocervical adenocarcinomas exhibit mucinous and/or endometrioid differentiation, they infrequently metastasize to the ovaries but may simulate primary ovarian tumors (both atypical proliferative or borderline and carcinoma). In patients with mucinous adenocarcino...
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Epithelial carcinoma of the ovary is one of the most common gynecological malignancies and the fifth most frequent cause of cancer death in women. Currently blood test of advanced epithelial tumors are reflected in a high level of CA 125 antigen. However, it is not a good marker for early stage tumors, and may yield false positives. Clearly, there is a need for better understanding of the molec...
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